Toshihide Takeuchi

Sakai, Japan

Last Updated: 09/26/2026

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Found 35 publications

Blood extracellular vesicles contribute to the exercise-mediated suppression of brain Aβ pathology in the AppNL-G-F knockin mouse model of Alzheimer's disease.

Blood extracellular vesicles contribute to the exercise-mediated suppression of brain Aβ pathology in the AppNL-G-F knockin mouse model of Alzheimer's disease.

Journal: Neurochemistry international

Published: November 18, 2025

Oral administration of arginine suppresses Aβ pathology in animal models of Alzheimer's disease.

Oral administration of arginine suppresses Aβ pathology in animal models of Alzheimer's disease.

Journal: Neurochemistry international

Published: September 22, 2025

Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.

Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.

Journal: Disease models & mechanisms

Published: May 07, 2025

Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles.

Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles.

Journal: Pharmaceutical research

Published: April 30, 2024

Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.

Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.

Journal: Acta neuropathologica communications

Published: September 01, 2023

CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy.

CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy.

Journal: Scientific reports

Published: September 01, 2023

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.

Journal: eLife

Published: July 18, 2023

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

Journal: Acta neuropathologica

Published: October 04, 2022

Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.

Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.

Journal: Human molecular genetics

Published: September 26, 2022

Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.

Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.

Journal: Molecular therapy. Nucleic acids

Published: April 22, 2022

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice.

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice.

Journal: Biomedicines

Published: March 28, 2022

Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics.

Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics.

Journal: Neurochemistry international

Published: January 31, 2022

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Last Updated: 09/26/2026