Toshihiro Imada

Shinjuku, 1608582, Japan

Last Updated: 09/26/2026

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Found 21 publications

Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.

Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.

Journal: Bioorganic & medicinal chemistry
Published: October 24, 2022

Lactoferrin Ameliorates Dry Eye Disease Potentially through Enhancement of Short-Chain Fatty Acid Production by Gut Microbiota in Mice.

Lactoferrin Ameliorates Dry Eye Disease Potentially through Enhancement of Short-Chain Fatty Acid Production by Gut Microbiota in Mice.

Journal: International journal of molecular sciences
Published: October 19, 2021

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice.

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice.

Journal: Nutrients
Published: June 18, 2021

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen.

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen.

Journal: Scientific reports
Published: November 22, 2020

Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.

Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.

Journal: Biochemical and biophysical research communications
Published: December 16, 2019

Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion.

Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion.

Journal: The American journal of pathology
Published: June 16, 2019

Corneal Sensory Experience via Transient Receptor Potential Vanilloid 1 Accelerates the Maturation of Neonatal Tearing.

Corneal Sensory Experience via Transient Receptor Potential Vanilloid 1 Accelerates the Maturation of Neonatal Tearing.

Journal: The American journal of pathology
Published: December 12, 2018

Enriched environment alleviates stress-induced dry-eye through the BDNF axis.

Enriched environment alleviates stress-induced dry-eye through the BDNF axis.

Journal: Scientific reports
Published: September 12, 2018

Intravital Two-photon Imaging of Ca2+ signaling in Secretory Organs of Yellow Cameleon Transgenic Mice.

Intravital Two-photon Imaging of Ca2+ signaling in Secretory Organs of Yellow Cameleon Transgenic Mice.

Journal: Scientific reports
Published: May 15, 2018

Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.

Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.

Journal: Aging cell
Published: September 26, 2017

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Journal: Bioorganic & medicinal chemistry
Published: April 01, 2017

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Journal: Bioorganic & medicinal chemistry
Published: March 11, 2017
Showing 1-12 of 21

Last Updated: 09/26/2026