Toshiyuki Takeuchi

Fujisawa, Japan

Last Updated: 09/26/2026

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Found 18 publications

Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners.

Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners.

Journal: Nutrients

Published: December 05, 2023

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery.

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery.

Journal: Science advances

Published: September 28, 2020

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.

Journal: Science advances

Published: September 10, 2018

The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells.

The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells.

Journal: The Journal of biological chemistry

Published: October 05, 2017

Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins.

Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: September 27, 2017

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3.

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3.

Journal: Cancer science

Published: March 20, 2017

Disposition and metabolism of TAK-438 (vonoprazan fumarate), a novel potassium-competitive acid blocker, in rats and dogs.

Disposition and metabolism of TAK-438 (vonoprazan fumarate), a novel potassium-competitive acid blocker, in rats and dogs.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: May 27, 2016

An essential role for functional lysosomes in ferroptosis of cancer cells.

An essential role for functional lysosomes in ferroptosis of cancer cells.

Journal: The Biochemical journal

Published: June 05, 2015

Mitochondrial respiratory function induces endogenous hypoxia.

Mitochondrial respiratory function induces endogenous hypoxia.

Journal: PloS one

Published: August 09, 2013

Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs.

Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs.

Journal: Biopharmaceutics & drug disposition

Published: January 08, 2013

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: December 27, 2012

Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase.

Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase.

Journal: Cancer science

Published: September 05, 2012

Showing 1-12 of 18

Last Updated: 09/26/2026