Valentina Fodale
IRBM Science Park
Rome, Italy
Rome, Italy
Last Updated: 09/26/2026
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Found 14 publications
Discovery and Preclinical Characterization of I-0436650, a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers.
Journal: Journal of medicinal chemistry
Published: April 13, 2026
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
Journal: Journal of medicinal chemistry
Published: September 15, 2023
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
Journal: ACS medicinal chemistry letters
Published: October 21, 2022
Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay.
Journal: Journal of Huntington's disease
Published: August 08, 2022
AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.
AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.
Journal: Brain : a journal of neurology
Published: January 28, 2022
Analysis of mutant and total huntingtin expression in Huntington's disease murine models.
Journal: Scientific reports
Published: June 24, 2020
Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy.
Journal: Science translational medicine
Published: March 25, 2020
Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay.
Journal: Journal of Huntington's disease
Published: November 11, 2017
Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
Journal: PloS one
Published: November 01, 2017
Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.
Journal: Scientific reports
Published: March 15, 2017
Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins.
Journal: Biochemical and biophysical research communications
Published: August 05, 2016
SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling.
Journal: Human molecular genetics
Published: May 16, 2016
Last Updated: 09/26/2026