Valentina Romano

Trieste, 34149, Italy

Last Updated: 09/26/2026

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Found 8 publications

Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.

Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.

Journal: Neurobiology of disease

Published: December 17, 2020

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Journal: The Journal of biological chemistry

Published: January 09, 2017

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.

Journal: Disease models & mechanisms

Published: September 24, 2015

The TDP-43 N-terminal domain structure at high resolution.

The TDP-43 N-terminal domain structure at high resolution.

Journal: The FEBS journal

Published: August 13, 2015

The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function.

The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function.

Journal: Prion

Published: January 31, 2015

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.

Journal: Human molecular genetics

Published: August 15, 2014

Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.

Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.

Journal: The Journal of biological chemistry

Published: January 12, 2012

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

Journal: Brain research

Published: December 16, 2011

Showing 1-8 of 8

Last Updated: 09/26/2026