Vincent Gembus

Rouen, France

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 12 publications

Redox Heterocyclic Platforms Engineered for Brain Drug Delivery and Beyond.

Redox Heterocyclic Platforms Engineered for Brain Drug Delivery and Beyond.

Journal: Chemical record (New York, N.Y.)

Published: February 10, 2026

Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.

Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.

Journal: RSC medicinal chemistry

Published: December 12, 2023

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.

Journal: Molecules (Basel, Switzerland)

Published: November 23, 2022

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy.

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy.

Journal: Molecules (Basel, Switzerland)

Published: March 04, 2019

Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.

Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.

Journal: European journal of medicinal chemistry

Published: February 16, 2018

Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.

Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.

Journal: European journal of medicinal chemistry

Published: October 20, 2017

Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.

Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.

Journal: Journal of medicinal chemistry

Published: June 15, 2017

Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation.

Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation.

Journal: ACS chemical neuroscience

Published: February 20, 2015

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH.

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH.

Journal: Organic & biomolecular chemistry

Published: January 14, 2014

Palladium catalyzed one-pot sequential Suzuki cross-coupling-direct C-H functionalization of imidazo[1,2-a]pyrazines.

Palladium catalyzed one-pot sequential Suzuki cross-coupling-direct C-H functionalization of imidazo[1,2-a]pyrazines.

Journal: Organic letters

Published: November 16, 2012

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.

Journal: European journal of medicinal chemistry

Published: August 20, 2012

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.

Journal: Organic & biomolecular chemistry

Published: February 04, 2012

Showing 1-12 of 12

Last Updated: 09/26/2026