Last Updated: 09/26/2026
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Found 16 publications
Discovery of a Novel Tripeptide Linker that Broadens the Therapeutic Window of Auristatin-Based Antibody-Drug Conjugates by Reducing Bone Marrow Toxicity.
Journal: Bioconjugate chemistry
Published: July 23, 2026
Critique on "Identifying poor prognostic factors in patients with spontaneous spinal epidural hematoma: Insights from 47 cases at a single institution".
Journal: Clinical neurology and neurosurgery
Published: November 17, 2025
Kinetic and mechanistic investigation toward the characterization of tucatinib inhibition of CYP3A4.
Kinetic and mechanistic investigation toward the characterization of tucatinib inhibition of CYP3A4.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 21, 2025
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads.
Journal: Xenobiotica; the fate of foreign compounds in biological systems
Published: September 16, 2024
SGN-B6A: A New Vedotin Antibody-Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications.
Journal: Molecular cancer therapeutics
Published: January 02, 2023
Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published: February 06, 2022
Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Journal: Cancer chemotherapy and pharmacology
Published: November 18, 2021
Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug.
Journal: Clinical pharmacology and therapeutics
Published: November 16, 2021
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: August 04, 2020
Successful Prediction of Positron Emission Tomography-Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics-Informed Relative Expression Factor Approach.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 20, 2020
Pitfalls in Predicting Hepatobiliary Drug Transport Using Human Sandwich-Cultured Hepatocytes.
Journal: The AAPS journal
Published: April 24, 2020
Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A.
Journal: Clinical pharmacology and therapeutics
Published: January 25, 2019
Last Updated: 09/26/2026