Wataru Obuchi

Tokyo, Japan

Last Updated: 09/26/2026

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Found 13 publications

Extracellular vesicles for the delivery of gene therapy.

Extracellular vesicles for the delivery of gene therapy.

Journal: Nature reviews bioengineering

Published: October 17, 2025

Structure-based design, synthesis, and evaluation of tetrahydrotriazolothiazepine derivatives as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Structure-based design, synthesis, and evaluation of tetrahydrotriazolothiazepine derivatives as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: August 05, 2025

DS-3939a: A TA-MUC1-Directed Antibody-Drug Conjugate with Broad Antitumor Activity.

DS-3939a: A TA-MUC1-Directed Antibody-Drug Conjugate with Broad Antitumor Activity.

Journal: Molecular cancer therapeutics

Published: April 03, 2025

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.

Journal: Journal of extracellular vesicles

Published: July 17, 2024

Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity.

Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity.

Journal: Bioorganic & medicinal chemistry

Published: June 28, 2024

Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.

Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.

Journal: European journal of pharmacology

Published: July 19, 2023

Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.

Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: November 02, 2022

RNA interference activity of single-stranded oligonucleotides linked between the passenger strand and the guide strand with an aryl phosphate linker.

RNA interference activity of single-stranded oligonucleotides linked between the passenger strand and the guide strand with an aryl phosphate linker.

Journal: Nucleosides, nucleotides & nucleic acids

Published: May 28, 2021

Design of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity.

Design of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity.

Journal: Nucleosides, nucleotides & nucleic acids

Published: September 12, 2019

Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

Journal: PloS one

Published: September 27, 2017

Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

Journal: Proteomics

Published: November 11, 2015

A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice.

A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice.

Journal: Fluids and barriers of the CNS

Published: March 21, 2013

Showing 1-12 of 13

Last Updated: 09/26/2026