Wayne P. Pearce

London, ENG WC1E6DD, United Kingdom

Last Updated: 09/26/2026

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Found 20 publications

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 17, 2025

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality.

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality.

Journal: Cellular and molecular life sciences : CMLS

Published: July 10, 2025

Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.

Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.

Journal: Disease models & mechanisms

Published: June 20, 2025

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.

Journal: Nature communications

Published: November 22, 2023

Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development.

Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development.

Journal: The Journal of pathology

Published: May 10, 2022

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.

Journal: Nature communications

Published: January 09, 2020

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: April 06, 2019

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Journal: Nature communications

Published: December 28, 2016

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Journal: Nature communications

Published: April 20, 2016

Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Journal: Nature

Published: April 07, 2016

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Journal: Science translational medicine

Published: October 29, 2015

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.

Journal: Diabetologia

Published: October 29, 2015

Showing 1-12 of 20

Last Updated: 09/26/2026