Wei-hsiang Huang
Montreal, QC, Canada
Last Updated: 09/26/2026
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Found 17 publications
CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1.
Journal: Genetics
Published: April 03, 2026
Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.
Journal: American journal of human genetics
Published: February 24, 2025
TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1+ adult-born dentate granule cells.
Journal: Molecular biology of the cell
Published: November 27, 2024
Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disorders.
Journal: bioRxiv : the preprint server for biology
Published: October 17, 2024
Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.
Journal: eLife
Published: November 13, 2023
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.
Journal: The Journal of comparative neurology
Published: April 13, 2023
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: October 18, 2022
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice.
Journal: The Journal of biological chemistry
Published: October 17, 2022
Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markers (MADM).
Journal: Methods in molecular biology (Clifton, N.J.)
Published: July 01, 2022
Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.
Journal: Human molecular genetics
Published: August 02, 2020
Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy.
Journal: Neuroscience and biobehavioral reviews
Published: May 06, 2020
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Journal: Neuron
Published: July 25, 2019
Last Updated: 09/26/2026