Wei S. Aik

Sar, 999077, China

Last Updated: 09/26/2026

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Found 15 publications

Discovery of Potent and Selective THRβ Agonists Based on an N-Benzoylglycine Scaffold for the Treatment of Metabolic Disorders.

Discovery of Potent and Selective THRβ Agonists Based on an N-Benzoylglycine Scaffold for the Treatment of Metabolic Disorders.

Journal: Journal of medicinal chemistry

Published: July 16, 2026

Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics.

Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics.

Journal: Advanced healthcare materials

Published: July 02, 2025

Reposition pathways of GTP in orthoflavivirus NS5-methyltransferase revealed by enhanced molecular dynamics simulations.

Reposition pathways of GTP in orthoflavivirus NS5-methyltransferase revealed by enhanced molecular dynamics simulations.

Journal: Physical chemistry chemical physics : PCCP

Published: June 04, 2025

Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB.

Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB.

Journal: Nucleic acids research

Published: March 17, 2025

Structural basis for Rab23 activation and a loss-of-function mutation in Carpenter syndrome.

Structural basis for Rab23 activation and a loss-of-function mutation in Carpenter syndrome.

Journal: The Journal of biological chemistry

Published: September 28, 2024

A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression.

A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression.

Journal: Cancer research

Published: July 10, 2024

In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.

In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.

Journal: bioRxiv : the preprint server for biology

Published: May 22, 2023

In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.

In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.

Journal: RNA (New York, N.Y.)

Published: May 10, 2023

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.

Journal: Nucleic acids research

Published: January 24, 2022

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 11, 2021

Reconstitution and biochemical assays of an active human histone pre-mRNA 3'-end processing machinery.

Reconstitution and biochemical assays of an active human histone pre-mRNA 3'-end processing machinery.

Journal: Methods in enzymology

Published: June 29, 2021

Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5'-3' exonuclease.

Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5'-3' exonuclease.

Journal: RNA (New York, N.Y.)

Published: May 05, 2020

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Last Updated: 09/26/2026