Wen-shan X. Liu

Tianjin Key Laboratory On Technologies Enabling Development Of Clinical Therapeutics And Diagnostics
Tianjin, 300070, China

Last Updated: 09/26/2026

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Found 9 publications

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

Journal: Bioorganic chemistry

Published: November 28, 2019

Identification of novel inhibitor of protein tyrosine phosphatases delta: structure-based pharmacophore modeling, virtual screening, flexible docking, molecular dynamics simulation, and post-molecular dynamics analysis.

Identification of novel inhibitor of protein tyrosine phosphatases delta: structure-based pharmacophore modeling, virtual screening, flexible docking, molecular dynamics simulation, and post-molecular dynamics analysis.

Journal: Journal of biomolecular structure & dynamics

Published: October 19, 2019

Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Journal: Journal of biomolecular structure & dynamics

Published: September 07, 2019

Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation.

Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation.

Journal: Journal of biomolecular structure & dynamics

Published: July 02, 2019

Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics.

Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics.

Journal: Journal of biomolecular structure & dynamics

Published: May 03, 2019

Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation.

Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation.

Journal: Journal of computer-aided molecular design

Published: December 27, 2018

Exploring the effect of inhibitor AKB-9778 on VE-PTP by molecular docking and molecular dynamics simulation.

Exploring the effect of inhibitor AKB-9778 on VE-PTP by molecular docking and molecular dynamics simulation.

Journal: Journal of cellular biochemistry

Published: December 20, 2018

Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study.

Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study.

Journal: Journal of biomolecular structure & dynamics

Published: November 11, 2017

Analysis of a Chinese Charcot-Marie-Tooth disease type 2D pedigree

Analysis of a Chinese Charcot-Marie-Tooth disease type 2D pedigree

Journal: Zhonghua yi xue za zhi

Published: August 02, 2017

Showing 1-9 of 9

Last Updated: 09/26/2026