Wenfu Tan
Shanghai, 201203, China
Last Updated: 09/26/2026
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Found 33 publications
Discovery of 1-(Azetidin-3-ylmethyl)-1H-benzo[d]imidazole Derivatives as Efficient GSTP1 Inhibitors for Gastric Cancer Treatment via Warhead Removal Strategy.
Journal: Journal of medicinal chemistry
Published: March 03, 2026
Transformable nanoassembly of CXCL16 peptide-SN38 conjugate improves intratumor permeation and retention in peritoneal metastases.
Journal: Journal of controlled release : official journal of the Controlled Release Society
Published: January 14, 2026
The PROTAC selectively degrading BCL-XL inhibits the growth of tumors and significantly synergizes with Paclitaxel.
Journal: Biochemical pharmacology
Published: August 02, 2024
Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, display synergistic antitumor effects on hepatocellular carcinoma with minimal hepatotoxicity.
Journal: Biochemical pharmacology
Published: June 11, 2024
A Selective FGFR1/2 PROTAC Degrader with Antitumor Activity.
Journal: Molecular cancer therapeutics
Published: October 19, 2023
BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2.
Journal: Biochemical pharmacology
Published: September 15, 2023
The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth.
Journal: Theranostics
Published: May 23, 2022
ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli.
Journal: Medical oncology (Northwood, London, England)
Published: April 23, 2022
c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis.
Journal: Biochimica et biophysica acta. Molecular cell research
Published: April 21, 2022
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway.
Journal: Journal of natural medicines
Published: October 21, 2021
PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation.
Journal: Cell death & disease
Published: January 08, 2021
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma.
Journal: Acta pharmaceutica Sinica. B
Published: May 07, 2020
Last Updated: 09/26/2026