Werner Held

Lausanne, VD, Switzerland

Last Updated: 09/26/2026

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Found 51 publications

Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.

Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.

Journal: Frontiers in immunology
Published: November 10, 2025

The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells.

The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells.

Journal: The Journal of experimental medicine
Published: October 12, 2025

PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8+ T cells.

PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8+ T cells.

Journal: Science immunology
Published: August 23, 2024

Emergence and fate of stem cell-like Tcf7+ CD8+ T cells during a primary immune response to viral infection.

Emergence and fate of stem cell-like Tcf7+ CD8+ T cells during a primary immune response to viral infection.

Journal: Science immunology
Published: November 17, 2023

Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis.

Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis.

Journal: iScience
Published: October 17, 2023

The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer.

The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer.

Journal: Nature
Published: May 29, 2023

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.

Journal: Immunity
Published: August 11, 2022

Stem-cell-like T cells have a specific entry gate to the tumor.

Stem-cell-like T cells have a specific entry gate to the tumor.

Journal: Cancer cell
Published: February 17, 2022

PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stable imprint of persistent antigen exposure.

PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stable imprint of persistent antigen exposure.

Journal: Cell reports
Published: November 10, 2021

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion.

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion.

Journal: Nature immunology
Published: September 09, 2021

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems.

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems.

Journal: Nature aging
Published: September 08, 2021

Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.

Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.

Journal: Immunity
Published: September 07, 2021
Showing 1-12 of 51

Last Updated: 09/26/2026