Wim Annaert

Leuven, VLG, Belgium

Last Updated: 09/26/2026

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Found 61 publications

N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C.

N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C.

Journal: PloS one

Published: March 20, 2026

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes.

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes.

Journal: Molecular neurodegeneration

Published: November 06, 2025

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer's Disease.

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer's Disease.

Journal: Research square

Published: September 05, 2025

The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer's disease.

The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer's disease.

Journal: Molecular neurodegeneration advances

Published: July 26, 2025

Lysosome repair fails in ageing and Alzheimer's disease.

Lysosome repair fails in ageing and Alzheimer's disease.

Journal: Nature cell biology

Published: March 27, 2025

Proximal partners of the organellar N-terminal acetyltransferase NAA60: insights into Golgi structure and transmembrane protein topology.

Proximal partners of the organellar N-terminal acetyltransferase NAA60: insights into Golgi structure and transmembrane protein topology.

Journal: Open biology

Published: February 18, 2025

Amyloid precursor protein carboxy-terminal fragments as catalyzers of endolysosomal dysfunction in Alzheimer's disease.

Amyloid precursor protein carboxy-terminal fragments as catalyzers of endolysosomal dysfunction in Alzheimer's disease.

Journal: Trends in neurosciences

Published: February 10, 2025

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.

Journal: Molecular neurodegeneration

Published: September 17, 2024

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.

Journal: Science (New York, N.Y.)

Published: May 30, 2024

Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function.

Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function.

Journal: International journal of molecular sciences

Published: April 11, 2024

Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.

Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.

Journal: Nature communications

Published: March 15, 2024

Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?

Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology

Published: January 26, 2024

Showing 1-12 of 61

Last Updated: 09/26/2026