Wim G. Schepens

Beerse, VLG 2340, Belgium

Last Updated: 09/26/2026

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Found 12 publications

Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins.

Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: March 24, 2026

VHH antibody loop guides design of a synthetic macrocyclic peptide that potently blocks influenza virus membrane fusion.

VHH antibody loop guides design of a synthetic macrocyclic peptide that potently blocks influenza virus membrane fusion.

Journal: Npj viruses

Published: September 09, 2025

Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.

Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.

Journal: Journal of medicinal chemistry

Published: August 26, 2025

Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.

Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.

Journal: Journal of medicinal chemistry

Published: February 11, 2025

Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.

Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.

Journal: Molecular cancer therapeutics

Published: April 27, 2021

Corrigendum to "Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].

Corrigendum to "Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].

Journal: Bioorganic & medicinal chemistry letters

Published: September 10, 2018

Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Journal: Bioorganic & medicinal chemistry letters

Published: April 09, 2018

A small-molecule fusion inhibitor of influenza virus is orally active in mice.

A small-molecule fusion inhibitor of influenza virus is orally active in mice.

Journal: Science (New York, N.Y.)

Published: December 07, 2017

Potent peptidic fusion inhibitors of influenza virus.

Potent peptidic fusion inhibitors of influenza virus.

Journal: Science (New York, N.Y.)

Published: March 06, 2017

The first one-pot synthesis of L-7-iodotryptophan from 7-iodoindole and serine, and an improved synthesis of other L-7-halotryptophans.

The first one-pot synthesis of L-7-iodotryptophan from 7-iodoindole and serine, and an improved synthesis of other L-7-halotryptophans.

Journal: Organic letters

Published: May 09, 2014

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.

Journal: Bioorganic & medicinal chemistry letters

Published: September 26, 2012

Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors.

Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: May 02, 2012

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Last Updated: 09/26/2026