Xavier Brazzolotto

Bretigny, 91220, France

Last Updated: 09/26/2026

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Found 63 publications

Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction.

Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction.

Journal: Journal of medicinal chemistry

Published: May 06, 2026

Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes.

Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes.

Journal: European journal of medicinal chemistry

Published: April 23, 2026

Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer's Disease.

Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer's Disease.

Journal: ACS chemical neuroscience

Published: April 13, 2026

Combining β2-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease.

Combining β2-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease.

Journal: RSC medicinal chemistry

Published: March 30, 2026

Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model.

Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model.

Journal: European journal of medicinal chemistry

Published: January 15, 2026

Integrative structural and kinetic analysis of the molecular basis for reduced carbamate inhibition in atypical butyrylcholinesterase.

Integrative structural and kinetic analysis of the molecular basis for reduced carbamate inhibition in atypical butyrylcholinesterase.

Journal: Chemico-biological interactions

Published: November 07, 2025

Dual cholinergic modulation in dementia: Quinuclidine carbamates targeting butyrylcholinesterase and α7 nicotinic receptor.

Dual cholinergic modulation in dementia: Quinuclidine carbamates targeting butyrylcholinesterase and α7 nicotinic receptor.

Journal: Chemico-biological interactions

Published: September 18, 2025

Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors.

Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors.

Journal: Journal of medicinal chemistry

Published: August 08, 2025

The product of Ellman's reaction inhibits cholinesterases.

The product of Ellman's reaction inhibits cholinesterases.

Journal: Protein science : a publication of the Protein Society

Published: July 21, 2025

N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors.

N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors.

Journal: Chemico-biological interactions

Published: June 30, 2025

Challenges and advances in the development of antidotes against A-series nerve agents.

Challenges and advances in the development of antidotes against A-series nerve agents.

Journal: Archives of toxicology

Published: June 24, 2025

Expanding the reactive chemistry toolbox - warhead screening for covalent butyrylcholinesterase inhibitors.

Expanding the reactive chemistry toolbox - warhead screening for covalent butyrylcholinesterase inhibitors.

Journal: Chemico-biological interactions

Published: June 17, 2025

Showing 1-12 of 63

Last Updated: 09/26/2026