Xavier Sainsily

Sherbrooke, QC, Canada

Last Updated: 09/26/2026

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Found 13 publications

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.

Journal: Journal of medicinal chemistry

Published: January 04, 2022

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.

Journal: Frontiers in pharmacology

Published: May 14, 2021

Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients.

Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients.

Journal: Scientific reports

Published: March 30, 2021

Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats.

Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats.

Journal: American journal of physiology. Heart and circulatory physiology

Published: February 26, 2021

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Journal: Journal of medicinal chemistry

Published: February 01, 2021

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.

Journal: Journal of medicinal chemistry

Published: December 22, 2020

A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects.

A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects.

Journal: Journal of medicinal chemistry

Published: February 21, 2018

The apelinergic system as an alternative to catecholamines in low-output septic shock.

The apelinergic system as an alternative to catecholamines in low-output septic shock.

Journal: Critical care (London, England)

Published: November 07, 2017

ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.

ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.

Journal: Critical care medicine

Published: August 05, 2017

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Journal: Organic & biomolecular chemistry

Published: December 08, 2016

Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.

Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.

Journal: Journal of medicinal chemistry

Published: March 18, 2016

Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.

Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.

Journal: Biochemical pharmacology

Published: June 19, 2014

Showing 1-12 of 13

Last Updated: 09/26/2026