Xi Xu

State Key Laboratory Of Natural Medicines, Jiangsu Key Laboratory Of Drug Design And Optimization
Nanjing, China

Last Updated: 09/26/2026

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Found 23 publications

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity.

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity.

Journal: Future medicinal chemistry

Published: March 12, 2026

Molecular mechanism of resistance to lonafarnib conferred by mutations in the cysteine-rich region of respiratory syncytial virus fusion glycoprotein and discovery of a lonafarnib-derived antiviral PROTAC.

Molecular mechanism of resistance to lonafarnib conferred by mutations in the cysteine-rich region of respiratory syncytial virus fusion glycoprotein and discovery of a lonafarnib-derived antiviral PROTAC.

Journal: Journal of virology

Published: December 09, 2025

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Journal: Journal of medicinal chemistry

Published: September 11, 2025

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders.

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: June 27, 2025

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

Journal: Journal of medicinal chemistry

Published: June 17, 2025

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency.

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: September 18, 2024

Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia.

Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia.

Journal: Journal of medicinal chemistry

Published: April 04, 2024

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer.

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer.

Journal: Journal of medicinal chemistry

Published: October 23, 2023

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective.

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective.

Journal: Medicinal research reviews

Published: September 20, 2023

Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.

Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.

Journal: Journal of medicinal chemistry

Published: September 07, 2022

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression.

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression.

Journal: Journal of medicinal chemistry

Published: July 05, 2022

Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles.

Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles.

Journal: Pharmaceutical development and technology

Published: December 13, 2021

Showing 1-12 of 23

Last Updated: 09/26/2026