Xiang-duan Tan

Guangxi Key Laboratory Of Drug Discovery And Optimization
Guilin, 541199, China

Last Updated: 09/26/2026

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Found 9 publications

Discovery of novel 1-(4-aminophenylacetyl)piperidine derivatives as FXR partial agonists for the potential treatment of metabolic dysfunction-associated steatohepatitis.

Discovery of novel 1-(4-aminophenylacetyl)piperidine derivatives as FXR partial agonists for the potential treatment of metabolic dysfunction-associated steatohepatitis.

Journal: European journal of medicinal chemistry

Published: August 16, 2025

Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification.

Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification.

Journal: Bioorganic & medicinal chemistry letters

Published: January 05, 2025

Design, synthesis and FXR partial agonistic activity of anthranilic acid derivatives bearing aryloxy moiety as therapeutic agents for metabolic dysfunction-associated steatohepatitis.

Design, synthesis and FXR partial agonistic activity of anthranilic acid derivatives bearing aryloxy moiety as therapeutic agents for metabolic dysfunction-associated steatohepatitis.

Journal: Bioorganic chemistry

Published: September 03, 2024

Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis.

Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis.

Journal: European journal of medicinal chemistry

Published: September 20, 2023

Synthesis and biological evaluation of novel pentanediamide derivatives as S-adenosyl-l-homocysteine hydrolase inhibitors.

Synthesis and biological evaluation of novel pentanediamide derivatives as S-adenosyl-l-homocysteine hydrolase inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: May 02, 2022

Identification of novel inhibitors of S-adenosyl-L-homocysteine hydrolase via structure-based virtual screening and molecular dynamics simulations.

Identification of novel inhibitors of S-adenosyl-L-homocysteine hydrolase via structure-based virtual screening and molecular dynamics simulations.

Journal: Journal of molecular modeling

Published: February 18, 2022

Discovery of novel N-aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors.

Discovery of novel N-aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors.

Journal: Chemical biology & drug design

Published: December 13, 2019

Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo.

Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo.

Journal: Molecules (Basel, Switzerland)

Published: July 27, 2019

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists.

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists.

Journal: Molecular diversity

Published: November 03, 2017

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Last Updated: 09/26/2026