Xiangkai Zhen

Fuzhou, 350117, China

Last Updated: 09/26/2026

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Found 20 publications

DNMT/TET Imbalance and Network-Level DNA Methylation Remodeling in Ovarian Aging: Mechanistic Perspectives.

DNMT/TET Imbalance and Network-Level DNA Methylation Remodeling in Ovarian Aging: Mechanistic Perspectives.

Journal: Biology

Published: February 23, 2026

Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system.

Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system.

Journal: Nature communications

Published: July 20, 2025

Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate.

Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate.

Journal: Molecular cell

Published: July 11, 2025

Dual regulation of HEPN RNase in fused MNT-HEPN toxin-antitoxin systems via protein OligoAMPylation and oligomerization.

Dual regulation of HEPN RNase in fused MNT-HEPN toxin-antitoxin systems via protein OligoAMPylation and oligomerization.

Journal: Nucleic acids research

Published: June 11, 2025

Mechanistic basis for the allosteric activation of NADase activity in the Sir2-HerA antiphage defense system.

Mechanistic basis for the allosteric activation of NADase activity in the Sir2-HerA antiphage defense system.

Journal: Nature communications

Published: March 12, 2024

Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system.

Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system.

Journal: Nature communications

Published: July 06, 2023

A secreted effector with a dual role as a toxin and as a transcriptional factor.

A secreted effector with a dual role as a toxin and as a transcriptional factor.

Journal: Nature communications

Published: June 29, 2022

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila.

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila.

Journal: Nature communications

Published: March 28, 2022

Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA.

Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA.

Journal: The Journal of biological chemistry

Published: December 09, 2021

Crystal structure of the MyRF ICA domain with its upstream β-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage.

Crystal structure of the MyRF ICA domain with its upstream β-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage.

Journal: International journal of biological sciences

Published: December 29, 2020

Structural and biochemical analyses of the tetrameric cell binding domain of Lys170 from enterococcal phage F170/08.

Structural and biochemical analyses of the tetrameric cell binding domain of Lys170 from enterococcal phage F170/08.

Journal: European biophysics journal : EBJ

Published: October 02, 2020

Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.

Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.

Journal: Nucleic acids research

Published: April 21, 2020

Showing 1-12 of 20

Last Updated: 09/26/2026