Xiao-dong Liu-Dong

Nanjing, China

Last Updated: 09/26/2026

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Found 56 publications

Prediction of pharmacokinetics and central nervous system effects of fentanyl and alfentanil in mice, rats, and humans using a cross-species physiologically based pharmacokinetic-pharmacodynamic model and in vitro pharmacokinetic/pharmacodynamic parameters.

Prediction of pharmacokinetics and central nervous system effects of fentanyl and alfentanil in mice, rats, and humans using a cross-species physiologically based pharmacokinetic-pharmacodynamic model and in vitro pharmacokinetic/pharmacodynamic parameters.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: February 09, 2026

Venlafaxine upregulates cortical catechol-O-methyltransferase expression and activity in rats and mice.

Venlafaxine upregulates cortical catechol-O-methyltransferase expression and activity in rats and mice.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 05, 2025

Clozapine impaired the hypoglycemic effect of metformin by inhibiting hepatic organic cation transporter 1 (OCT1).

Clozapine impaired the hypoglycemic effect of metformin by inhibiting hepatic organic cation transporter 1 (OCT1).

Journal: Acta pharmacologica Sinica

Published: June 22, 2025

Bile duct ligation impairs function and expression of breast cancer resistance protein in rat blood-retinal barrier mainly due to both the increased ammonia and bilirubin.

Bile duct ligation impairs function and expression of breast cancer resistance protein in rat blood-retinal barrier mainly due to both the increased ammonia and bilirubin.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: June 19, 2025

Cisplatin-induced acute kidney injury increased brain 5-hydroxytryptamine levels partly due to the hippuric acid-induced upregulation of CYP2D4 expression and function in the brain of rats.

Cisplatin-induced acute kidney injury increased brain 5-hydroxytryptamine levels partly due to the hippuric acid-induced upregulation of CYP2D4 expression and function in the brain of rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: December 18, 2024

Acute liver failure-induced arginine deficiency impairs blood-brain barrier via inhibiting mTORC1-S6K1/4EBP1 pathway and inducing autophagy.

Acute liver failure-induced arginine deficiency impairs blood-brain barrier via inhibiting mTORC1-S6K1/4EBP1 pathway and inducing autophagy.

Journal: Cell death & disease

Published: November 14, 2024

Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier.

Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: August 30, 2024

Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice.

Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice.

Journal: Acta pharmacologica Sinica

Published: June 06, 2024

Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model.

Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: May 21, 2024

Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration.

Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration.

Journal: Acta pharmacologica Sinica

Published: March 15, 2024

PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans.

PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans.

Journal: Acta pharmacologica Sinica

Published: December 21, 2023

Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury.

Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury.

Journal: Acta pharmacologica Sinica

Published: October 18, 2023

Showing 1-12 of 56

Last Updated: 09/26/2026