Xiao-feng Xiong

Guangdong Key Laboratory Of Chiral Molecule And Drug Discovery
Guangzhou, 510006, China

Last Updated: 09/26/2026

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Found 28 publications

Triflic Acid-Mediated Chemoselective Indole C2-Heteroarylation of Peptide Tryptophan Residues by Triazine.

Triflic Acid-Mediated Chemoselective Indole C2-Heteroarylation of Peptide Tryptophan Residues by Triazine.

Journal: Organic letters

Published: December 09, 2024

Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2.

Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2.

Journal: Journal of medicinal chemistry

Published: September 04, 2024

Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer.

Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer.

Journal: Journal of medicinal chemistry

Published: January 16, 2024

Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma.

Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma.

Journal: Bioorganic chemistry

Published: October 16, 2023

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Journal: Bioorganic & medicinal chemistry

Published: July 15, 2023

Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.

Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.

Journal: European journal of medicinal chemistry

Published: September 14, 2022

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.

Journal: European journal of medicinal chemistry

Published: April 15, 2022

Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.

Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.

Journal: Biochemical pharmacology

Published: April 07, 2022

On-Resin Synthesis of Linear Aryl Thioether Containing Peptides and in-Solution Cyclization via Cysteine SNAr Reaction.

On-Resin Synthesis of Linear Aryl Thioether Containing Peptides and in-Solution Cyclization via Cysteine SNAr Reaction.

Journal: Organic letters

Published: February 23, 2022

Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.

Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.

Journal: Journal of medicinal chemistry

Published: February 21, 2022

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.

Journal: Acta pharmaceutica Sinica. B

Published: February 04, 2022

Demethylative Alkylation of Methionine Residue by Employing the Sulfonium as the Key Intermediate.

Demethylative Alkylation of Methionine Residue by Employing the Sulfonium as the Key Intermediate.

Journal: Organic letters

Published: October 20, 2021

Showing 1-12 of 28

Last Updated: 09/26/2026