Xiao-hua Chen

No. 19A Yuquan Road
Yuquan, 100049, China

Last Updated: 09/26/2026

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Found 24 publications

CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.

CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor.

Journal: Theranostics
Published: January 21, 2026

A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders.

A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders.

Journal: Angewandte Chemie (International ed. in English)
Published: January 07, 2026

Genetically Encoded Lysine-Selective Photocyclization Enables Phage Display Selection of Cyclic Peptide Binders.

Genetically Encoded Lysine-Selective Photocyclization Enables Phage Display Selection of Cyclic Peptide Binders.

Journal: Angewandte Chemie (International ed. in English)
Published: December 08, 2025

Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells.

Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells.

Journal: Angewandte Chemie (International ed. in English)
Published: March 31, 2025

Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries.

Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries.

Journal: Angewandte Chemie (International ed. in English)
Published: March 10, 2025

Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space.

Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space.

Journal: Angewandte Chemie (International ed. in English)
Published: March 03, 2025

A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli.

A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli.

Journal: Nature communications
Published: January 22, 2025

General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.

General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.

Journal: JACS Au
Published: January 06, 2025

Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer.

Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer.

Journal: Bioorganic chemistry
Published: August 16, 2024

Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A.

Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A.

Journal: Acta pharmacologica Sinica
Published: June 25, 2024

Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer.

Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer.

Journal: Journal of medicinal chemistry
Published: June 17, 2024

Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry.

Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: January 25, 2024
Showing 1-12 of 24

Last Updated: 09/26/2026