Xiao-jin Zhang

Jiangsu Key Laboratory Of Druggability Of Biopharmaceuticals, State Key Laboratory Of Natural Medicines
Nanjing, 211198, China

Last Updated: 09/26/2026

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Found 19 publications

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.

Journal: Acta pharmacologica Sinica

Published: June 26, 2022

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.

Journal: Bioorganic chemistry

Published: September 15, 2017

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.

Journal: European journal of medicinal chemistry

Published: March 16, 2017

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

Journal: Bioorganic & medicinal chemistry

Published: August 31, 2016

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

Journal: European journal of medicinal chemistry

Published: May 09, 2016

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Journal: Journal of medicinal chemistry

Published: August 11, 2015

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Journal: European journal of medicinal chemistry

Published: July 22, 2015

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Journal: Journal of medicinal chemistry

Published: June 26, 2015

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

Journal: Scientific reports

Published: February 08, 2015

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.

Journal: Journal of computer-aided molecular design

Published: June 08, 2014

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Journal: Journal of medicinal chemistry

Published: February 12, 2014

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

Journal: Journal of medicinal chemistry

Published: September 24, 2013

Showing 1-12 of 19

Last Updated: 09/26/2026