Xiaolei Zhang

State Key Laboratory Of Anti Infective Drug Discovery And Development, Guangdong Key Laboratory Of Chiral Molecule And Drug Discovery
Guangzhou, China

Last Updated: 09/26/2026

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Found 21 publications

Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia.

Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia.

Journal: Cell death & disease

Published: November 29, 2025

Single intravitreal injection of lipid nanoparticles delivering circular mRNA of nicotinamide phosphoribosyltransferase protects against dry AMD.

Single intravitreal injection of lipid nanoparticles delivering circular mRNA of nicotinamide phosphoribosyltransferase protects against dry AMD.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: August 30, 2025

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin-mediated Phagocytic Effects for Lung Cancer Treatment.

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin-mediated Phagocytic Effects for Lung Cancer Treatment.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: May 07, 2025

The IGF2BP3-FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer.

The IGF2BP3-FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer.

Journal: Cell death & disease

Published: February 08, 2025

Metabolic reprogramming of tumor-associated macrophages via adenosine-A2AR signaling drives cross-resistance in non-small cell lung cancer.

Metabolic reprogramming of tumor-associated macrophages via adenosine-A2AR signaling drives cross-resistance in non-small cell lung cancer.

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Published: January 31, 2025

A novel adenosine 2A receptor antagonist HZ-086 enhances the efficiency of immunotherapy and alleviates the acquired resistance to PD-L1 by restoration of T cell functions.

A novel adenosine 2A receptor antagonist HZ-086 enhances the efficiency of immunotherapy and alleviates the acquired resistance to PD-L1 by restoration of T cell functions.

Journal: European journal of pharmacology

Published: November 02, 2024

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer.

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer.

Journal: Journal of experimental & clinical cancer research : CR

Published: September 05, 2024

Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.

Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma.

Journal: Acta pharmacologica Sinica

Published: November 17, 2023

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Journal: Bioorganic & medicinal chemistry

Published: July 15, 2023

Reprogramming of TAMs via the STAT3/CD47-SIRPα axis promotes acquired resistance to EGFR-TKIs in lung cancer.

Reprogramming of TAMs via the STAT3/CD47-SIRPα axis promotes acquired resistance to EGFR-TKIs in lung cancer.

Journal: Cancer letters

Published: January 16, 2023

Targeting STAT3-VISTA axis to suppress tumor aggression and burden in acute myeloid leukemia.

Targeting STAT3-VISTA axis to suppress tumor aggression and burden in acute myeloid leukemia.

Journal: Journal of hematology & oncology

Published: December 16, 2022

Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.

Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway.

Journal: European journal of medicinal chemistry

Published: September 19, 2022

Showing 1-12 of 21

Last Updated: 09/26/2026