Last Updated: 09/26/2026
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Found 10 publications
Discovery of MK-5661, a Once-Daily Oral NaV1.8 Inhibitor for the Treatment of Pain.
Journal: ACS medicinal chemistry letters
Published: March 06, 2026
Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors.
Journal: Neurobiology of pain (Cambridge, Mass.)
Published: October 28, 2024
2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model.
Journal: ACS medicinal chemistry letters
Published: March 04, 2024
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Journal: Journal of medicinal chemistry
Published: December 21, 2021
Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose.
Journal: Frontiers in pharmacology
Published: September 29, 2021
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
Journal: The Journal of pharmacology and experimental therapeutics
Published: October 30, 2019
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Journal: Journal of medicinal chemistry
Published: March 01, 2017
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
Journal: The Journal of pharmacology and experimental therapeutics
Published: August 06, 2015
Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.
Journal: Bioorganic & medicinal chemistry letters
Published: July 24, 2014
Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Journal: Bioorganic & medicinal chemistry letters
Published: April 22, 2014
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Last Updated: 09/26/2026