Xiaowei Zhong

Calgary, AB T2N4N1, Canada

Last Updated: 09/26/2026

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Found 12 publications

RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.

RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.

Journal: The Biochemical journal

Published: June 19, 2023

Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome.

Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome.

Journal: JAMA cardiology

Published: November 03, 2021

Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death.

Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death.

Journal: Bioscience reports

Published: January 24, 2021

Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart.

Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart.

Journal: Circulation research

Published: December 30, 2020

Cardiac ryanodine receptor calcium release deficiency syndrome.

Cardiac ryanodine receptor calcium release deficiency syndrome.

Journal: Science translational medicine

Published: December 30, 2019

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts.

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts.

Journal: The Journal of biological chemistry

Published: April 29, 2018

Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans.

Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans.

Journal: The Biochemical journal

Published: August 10, 2017

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

Journal: The Biochemical journal

Published: June 23, 2016

The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.

The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.

Journal: The Biochemical journal

Published: April 25, 2014

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Journal: Nature medicine

Published: September 01, 2013

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Journal: Circulation research

Published: July 17, 2013

Conformational dynamics inside amino-terminal disease hotspot of ryanodine receptor.

Conformational dynamics inside amino-terminal disease hotspot of ryanodine receptor.

Journal: Structure (London, England : 1993)

Published: April 08, 2013

Showing 1-12 of 12

Last Updated: 09/26/2026