Xiaoying Cai

Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 22 publications

Non-covalent mTOR inhibition suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis.

Non-covalent mTOR inhibition suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis.

Journal: Biochemical pharmacology

Published: August 24, 2025

Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis.

Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis.

Journal: Journal of pharmaceutical analysis

Published: June 30, 2025

VCP's nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage.

VCP's nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 08, 2025

Neuroprotective alpha-linolenic acid derived from black pepper targets PGK1 and activates the Nrf2 pathway in PC12 cells and mice.

Neuroprotective alpha-linolenic acid derived from black pepper targets PGK1 and activates the Nrf2 pathway in PC12 cells and mice.

Journal: European journal of pharmacology

Published: March 08, 2025

Valtrate alleviates inflammation by targeting USP9X to enhance NLRP3 degradation.

Valtrate alleviates inflammation by targeting USP9X to enhance NLRP3 degradation.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

Published: March 05, 2025

Mechanisms and therapeutic strategies for NLRP3 degradation via post-translational modifications in ubiquitin-proteasome and autophagy lysosomal pathway.

Mechanisms and therapeutic strategies for NLRP3 degradation via post-translational modifications in ubiquitin-proteasome and autophagy lysosomal pathway.

Journal: European journal of medicinal chemistry

Published: December 13, 2024

Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease.

Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease.

Journal: Journal of medicinal chemistry

Published: September 23, 2024

Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis.

Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis.

Journal: Journal of medicinal chemistry

Published: August 22, 2024

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.

Journal: Science advances

Published: February 07, 2024

Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.

Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.

Journal: Journal of medicinal chemistry

Published: October 25, 2023

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.

Journal: Journal of medicinal chemistry

Published: September 27, 2023

Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury.

Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury.

Journal: Journal of medicinal chemistry

Published: August 15, 2023

Showing 1-12 of 22

Last Updated: 09/26/2026