Xilin H. Lyu

State Key Laboratory Of Drug Research, 555 Zuchongzhi Rd
Shanghai, 201203, China

Last Updated: 09/26/2026

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Found 18 publications

Discovery and characterization of YSA64, a RBM39 degrader with in vivo efficacy and potent cellular activity in pediatric Ewing sarcoma A673.

Discovery and characterization of YSA64, a RBM39 degrader with in vivo efficacy and potent cellular activity in pediatric Ewing sarcoma A673.

Journal: European journal of medicinal chemistry

Published: March 13, 2026

N‑Iminopyridinium Ylides as Chemically Stable Pharmacophores Enabling Targeted Degradation of SMARCA Proteins.

N‑Iminopyridinium Ylides as Chemically Stable Pharmacophores Enabling Targeted Degradation of SMARCA Proteins.

Journal: JACS Au

Published: January 06, 2026

Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures.

Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures.

Journal: Journal of medicinal chemistry

Published: March 19, 2025

Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo.

Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo.

Journal: Journal of medicinal chemistry

Published: January 13, 2025

Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.

Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.

Journal: Journal of medicinal chemistry

Published: June 24, 2024

Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction.

Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction.

Journal: European journal of medicinal chemistry

Published: February 05, 2024

Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach.

Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach.

Journal: Journal of medicinal chemistry

Published: January 03, 2024

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.

Journal: Journal of medicinal chemistry

Published: December 08, 2023

Research advances on the mechanism of circular RNA in diabetic wound healing

Research advances on the mechanism of circular RNA in diabetic wound healing

Journal: Zhonghua shao shang yu chuang mian xiu fu za zhi

Published: October 08, 2023

Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives.

Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives.

Journal: Molecules (Basel, Switzerland)

Published: January 27, 2023

Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.

Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.

Journal: European journal of medicinal chemistry

Published: November 09, 2022

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Journal: Journal of medicinal chemistry

Published: April 14, 2022

Showing 1-12 of 18

Last Updated: 09/26/2026