Xin L. Chai

Hangzhou, 310058, China

Last Updated: 09/26/2026

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Found 26 publications

A novel small-molecule androgen receptor antagonist selective for the T878A-mutant AR in prostate cancer therapy.

A novel small-molecule androgen receptor antagonist selective for the T878A-mutant AR in prostate cancer therapy.

Journal: European journal of medicinal chemistry

Published: February 06, 2026

Unraveling the Efficacy of AR Antagonists Bearing N-(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations.

Unraveling the Efficacy of AR Antagonists Bearing N-(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations.

Journal: Journal of medicinal chemistry

Published: June 03, 2025

Discovery of N-(1,2,4-Thiadiazol-5-yl)benzo[b]oxepine-4-carboxamide Derivatives as Novel Antiresistance Androgen Receptor Antagonists.

Discovery of N-(1,2,4-Thiadiazol-5-yl)benzo[b]oxepine-4-carboxamide Derivatives as Novel Antiresistance Androgen Receptor Antagonists.

Journal: Journal of medicinal chemistry

Published: January 23, 2025

Discovery of 5-Nitro-N-(3-(trifluoromethyl)phenyl) Pyridin-2-amine as a Novel Pure Androgen Receptor Antagonist against Antiandrogen Resistance.

Discovery of 5-Nitro-N-(3-(trifluoromethyl)phenyl) Pyridin-2-amine as a Novel Pure Androgen Receptor Antagonist against Antiandrogen Resistance.

Journal: Journal of medicinal chemistry

Published: November 07, 2024

Discovery of Thiadiazoleamide Derivatives as Potent, Selective, and Orally Available Antagonists Disrupting Androgen Receptor Homodimer.

Discovery of Thiadiazoleamide Derivatives as Potent, Selective, and Orally Available Antagonists Disrupting Androgen Receptor Homodimer.

Journal: Journal of medicinal chemistry

Published: September 28, 2024

Discovery of N-(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis.

Discovery of N-(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis.

Journal: Journal of medicinal chemistry

Published: January 17, 2024

A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model.

A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model.

Journal: Acta pharmacologica Sinica

Published: January 10, 2024

Discovery of Novel Anti-Resistance AR Antagonists Guided by Funnel Metadynamics Simulation.

Discovery of Novel Anti-Resistance AR Antagonists Guided by Funnel Metadynamics Simulation.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: November 29, 2023

Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance.

Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance.

Journal: Acta pharmacologica Sinica

Published: October 28, 2022

Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor.

Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor.

Journal: Journal of medicinal chemistry

Published: September 26, 2022

Discovery of novel non-nucleoside inhibitors with high potency and selectivity for DNA methyltransferase 3A.

Discovery of novel non-nucleoside inhibitors with high potency and selectivity for DNA methyltransferase 3A.

Journal: European journal of medicinal chemistry

Published: June 15, 2022

Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2.

Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2.

Journal: Journal of medicinal chemistry

Published: January 25, 2022

Showing 1-12 of 26

Last Updated: 09/26/2026