Xiong-jie Shi

Hubei Key Laboratory Of Cell Homeostasis
Wuhan, 430072, China

Last Updated: 09/26/2026

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Found 14 publications

Chronic Exposure to Environmental Concentrations of Tetrabromobisphenol A Disrupts Insulin and Lipid Homeostasis in Diet-Induced Obese Mice.

Chronic Exposure to Environmental Concentrations of Tetrabromobisphenol A Disrupts Insulin and Lipid Homeostasis in Diet-Induced Obese Mice.

Journal: Environmental science & technology
Published: February 25, 2025

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.

Journal: Journal of lipid research
Published: June 30, 2023

GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum.

GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum.

Journal: The EMBO journal
Published: April 23, 2022

Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.

Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.

Journal: Circulation
Published: February 22, 2022

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.

Journal: Nature
Published: August 22, 2021

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.

Journal: Protein & cell
Published: April 12, 2020

Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.

Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.

Journal: Nature
Published: November 13, 2019

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.

Journal: Journal of lipid research
Published: June 17, 2019

Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.

Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.

Journal: Nature metabolism
Published: January 24, 2019

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.

Journal: Nature communications
Published: October 07, 2018

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.

Journal: Nature communications
Published: July 12, 2018

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.

Journal: The Journal of biological chemistry
Published: December 04, 2017
Showing 1-12 of 14

Last Updated: 09/26/2026