Xixin He

Guangzhou, 510006, China

Last Updated: 09/26/2026

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Found 24 publications

Discovery of kaempferol derivatives as novel PDE4 inhibitors for treatment of idiopathic pulmonary fibrosis.

Discovery of kaempferol derivatives as novel PDE4 inhibitors for treatment of idiopathic pulmonary fibrosis.

Journal: European journal of medicinal chemistry

Published: September 27, 2025

A novel PDE4A inhibitor suppresses hepatocellular carcinoma progression through activating the cAMP-induced PKA pathway.

A novel PDE4A inhibitor suppresses hepatocellular carcinoma progression through activating the cAMP-induced PKA pathway.

Journal: Chemico-biological interactions

Published: September 22, 2025

Xg-13, a derivate of marine natural product, exhibits anti-angiogenesis ability in hepatocellular carcinoma via inhibiting Axl signaling pathway.

Xg-13, a derivate of marine natural product, exhibits anti-angiogenesis ability in hepatocellular carcinoma via inhibiting Axl signaling pathway.

Journal: Biochemical pharmacology

Published: January 23, 2025

Artemisinin analogues are effective in the treatment of psoriasis by targeting RORγt.

Artemisinin analogues are effective in the treatment of psoriasis by targeting RORγt.

Journal: Molecular immunology

Published: November 11, 2024

α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance.

α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance.

Journal: Molecular immunology

Published: August 17, 2023

Correction to "Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury".

Correction to "Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury".

Journal: ACS chemical neuroscience

Published: July 07, 2023

Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.

Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.

Journal: European journal of medicinal chemistry

Published: May 15, 2022

Synthesis and biological evaluation of marine natural product, Cryptoechinuline D derivatives as novel antiangiogenic agents.

Synthesis and biological evaluation of marine natural product, Cryptoechinuline D derivatives as novel antiangiogenic agents.

Journal: Bioorganic & medicinal chemistry letters

Published: January 03, 2022

Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.

Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.

Journal: Journal of medicinal chemistry

Published: September 14, 2021

The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry.

The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry.

Journal: European journal of medicinal chemistry

Published: August 24, 2021

5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development.

5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development.

Journal: Immunologic research

Published: December 13, 2020

Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells.

Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells.

Journal: Molecular immunology

Published: September 13, 2020

Showing 1-12 of 24

Last Updated: 09/26/2026