Xiyuan Hu

Hunan Key Laboratory Of Diagnostic And Therapeutic Drug Research For Chronic Diseases
Changsha, 410013, China

Last Updated: 09/26/2026

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Found 9 publications

Discovery of a novel napabucasin derivative B16 as a potent STAT3 inhibitor for the treatment of triple-negative breast cancer.

Discovery of a novel napabucasin derivative B16 as a potent STAT3 inhibitor for the treatment of triple-negative breast cancer.

Journal: European journal of medicinal chemistry

Published: August 02, 2025

LM2I leads to CAD ubiquitination and liver cancer suppression through activation of ASS1.

LM2I leads to CAD ubiquitination and liver cancer suppression through activation of ASS1.

Journal: Acta biochimica et biophysica Sinica

Published: May 31, 2025

ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance.

ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance.

Journal: Hepatology communications

Published: February 07, 2025

Naphthoquinone-derived ZSW-4B induces apoptosis in triple-negative breast cancer via AMPK signalling activation.

Naphthoquinone-derived ZSW-4B induces apoptosis in triple-negative breast cancer via AMPK signalling activation.

Journal: Scientific reports

Published: January 27, 2024

Spinosyn A and Its Derivative Inhibit Colorectal Cancer Cell Growth via the EGFR Pathway.

Spinosyn A and Its Derivative Inhibit Colorectal Cancer Cell Growth via the EGFR Pathway.

Journal: Journal of natural products

Published: September 08, 2023

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis.

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis.

Journal: Cell death & disease

Published: August 02, 2023

An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.

An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.

Journal: Cancers

Published: March 17, 2023

Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer.

Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer.

Journal: Frontiers in oncology

Published: November 30, 2022

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor.

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor.

Journal: Nature communications

Published: February 28, 2020

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Last Updated: 09/26/2026