Xue-chu Zhen

Jiangsu Key Laboratory Of Drug Discovery And Translational Research For Brain Diseases
Suzhou, 215123, China

Last Updated: 09/26/2026

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Found 53 publications

Rational Design of Gi-biased CB1 Agonists for the Next Generation of Analgesic Drug.

Rational Design of Gi-biased CB1 Agonists for the Next Generation of Analgesic Drug.

Journal: Neuroscience bulletin

Published: May 07, 2026

Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development.

Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development.

Journal: Acta pharmacologica Sinica

Published: December 29, 2025

Discovery of New N-H Aporphine Derivatives As Brain-Penetrant Gq-Biased 5-HT2C Receptor Agonists and Dual 5-HT2C/5-HT2A Receptor Agonists.

Discovery of New N-H Aporphine Derivatives As Brain-Penetrant Gq-Biased 5-HT2C Receptor Agonists and Dual 5-HT2C/5-HT2A Receptor Agonists.

Journal: Journal of medicinal chemistry

Published: October 18, 2025

Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway.

Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway.

Journal: Acta pharmacologica Sinica

Published: September 24, 2025

Mechanistic insights into pharmacokinetic interactions between simvastatin and vismodegib: Implications for optimization of combination therapy in medulloblastoma.

Mechanistic insights into pharmacokinetic interactions between simvastatin and vismodegib: Implications for optimization of combination therapy in medulloblastoma.

Journal: Biochemical and biophysical research communications

Published: August 20, 2025

Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.

Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.

Journal: Oncogene

Published: August 11, 2025

Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics.

Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics.

Journal: Acta pharmacologica Sinica

Published: March 07, 2025

Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway.

Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway.

Journal: Acta pharmacologica Sinica

Published: February 10, 2025

Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway.

Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway.

Journal: Cell reports

Published: April 03, 2024

Nanomodulators targeting endothelial WNT and pericytes to reversibly open the blood-tumor barrier for boosted brain tumor therapy.

Nanomodulators targeting endothelial WNT and pericytes to reversibly open the blood-tumor barrier for boosted brain tumor therapy.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: October 22, 2023

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator.

The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator.

Journal: Acta pharmacologica Sinica

Published: October 19, 2023

Targeted to neuronal organelles for CNS drug development.

Targeted to neuronal organelles for CNS drug development.

Journal: Advanced drug delivery reviews

Published: April 30, 2023

Showing 1-12 of 53

Last Updated: 09/26/2026