Xuechu C. Zhen

Jiangsu Key Laboratory Of Drug Discovery And Translational Research For Brain Diseases And College Of Pharmaceutical Sciences
Suzhou, 215123, China

Last Updated: 09/26/2026

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Found 79 publications

Vitamin K3 alleviates brain injury and behavioral deficits by inhibiting neuroinflammation in intracerebral hemorrhage in vitro and in vivo.

Vitamin K3 alleviates brain injury and behavioral deficits by inhibiting neuroinflammation in intracerebral hemorrhage in vitro and in vivo.

Journal: International immunopharmacology

Published: January 21, 2026

Structural insights into the MLH1-FAN1 interaction reveal an uncharacterized binding interface on MLH1.

Structural insights into the MLH1-FAN1 interaction reveal an uncharacterized binding interface on MLH1.

Journal: Nature communications

Published: November 21, 2025

Differential modulation of BK channels by simvastatin: Critical role of the auxiliary β4 subunit.

Differential modulation of BK channels by simvastatin: Critical role of the auxiliary β4 subunit.

Journal: British journal of pharmacology

Published: September 01, 2025

Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins.

Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins.

Journal: Nature communications

Published: May 13, 2025

De novo design of GPCR exoframe modulators.

De novo design of GPCR exoframe modulators.

Journal: Nature

Published: January 23, 2025

Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development.

Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development.

Journal: Acta pharmaceutica Sinica. B

Published: January 05, 2025

Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.

Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.

Journal: Neuropharmacology

Published: December 03, 2024

Biomimetic membrane-coated nanoparticles specially permeate the inflammatory blood-brain barrier to deliver plasmin therapy for brain metastases.

Biomimetic membrane-coated nanoparticles specially permeate the inflammatory blood-brain barrier to deliver plasmin therapy for brain metastases.

Journal: Journal of controlled release : official journal of the Controlled Release Society

Published: September 05, 2024

'Whole-Body' Perspectives of Schizophrenia and Related Psychotic Illness: miRNA-143 as an Exemplary Molecule Implicated across Multi-System Dysfunctions.

'Whole-Body' Perspectives of Schizophrenia and Related Psychotic Illness: miRNA-143 as an Exemplary Molecule Implicated across Multi-System Dysfunctions.

Journal: Biomolecules

Published: July 12, 2024

Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities.

Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities.

Journal: Medicinal research reviews

Published: June 04, 2024

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.

Journal: Cell death & disease

Published: February 20, 2024

Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice.

Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice.

Journal: Neurochemical research

Published: November 19, 2023

Showing 1-12 of 79

Last Updated: 09/26/2026