Yanlin Jian

#277 Yanta West Road
Xi'an, China

Last Updated: 09/26/2026

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Found 17 publications

Mirror-Peptidizer: In Silico Mirror-Image Screening Enables De Novo Design of D-Peptide Binders without D-Protein Synthesis.

Mirror-Peptidizer: In Silico Mirror-Image Screening Enables De Novo Design of D-Peptide Binders without D-Protein Synthesis.

Journal: Research (Washington, D.C.)
Published: March 23, 2026

Multi-stimuli activated PROTAC prodrug for controlled protein degradation with enhanced therapeutic effects.

Multi-stimuli activated PROTAC prodrug for controlled protein degradation with enhanced therapeutic effects.

Journal: European journal of medicinal chemistry
Published: August 22, 2025

RAD51-targeting small molecule degrader sensitizes BRCA-proficient prostate cancer cells to PARP inhibitors via synthetic lethality.

RAD51-targeting small molecule degrader sensitizes BRCA-proficient prostate cancer cells to PARP inhibitors via synthetic lethality.

Journal: Acta pharmaceutica Sinica. B
Published: August 04, 2025

A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition.

A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition.

Journal: Cancer research
Published: November 01, 2024

A proximity-induced chimera platform for targeted protein arginine methylation.

A proximity-induced chimera platform for targeted protein arginine methylation.

Journal: Acta pharmaceutica Sinica. B
Published: August 10, 2024

A Top-Down Design Approach for Generating a Peptide PROTAC Drug Targeting Androgen Receptor for Androgenetic Alopecia Therapy.

A Top-Down Design Approach for Generating a Peptide PROTAC Drug Targeting Androgen Receptor for Androgenetic Alopecia Therapy.

Journal: Journal of medicinal chemistry
Published: June 05, 2024

CK2-dependent degradation of CBX3 dictates replication fork stalling and PARP inhibitor sensitivity.

CK2-dependent degradation of CBX3 dictates replication fork stalling and PARP inhibitor sensitivity.

Journal: Science advances
Published: May 23, 2024

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Journal: Cell metabolism
Published: April 29, 2024

DTX3L-mediated TIRR nuclear export and degradation regulates DNA repair pathway choice and PARP inhibitor sensitivity.

DTX3L-mediated TIRR nuclear export and degradation regulates DNA repair pathway choice and PARP inhibitor sensitivity.

Journal: Nature communications
Published: April 02, 2024

Development of a Double-Stapled Peptide Stabilizing Both α-Helix and β-Sheet Structures for Degrading Transcription Factor AR-V7.

Development of a Double-Stapled Peptide Stabilizing Both α-Helix and β-Sheet Structures for Degrading Transcription Factor AR-V7.

Journal: JACS Au
Published: December 14, 2023

Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response.

Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response.

Journal: EBioMedicine
Published: October 10, 2023

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.

Journal: Nature communications
Published: June 24, 2023
Showing 1-12 of 17

Last Updated: 09/26/2026