Yassine El Hiani

Halifax, NS, Canada

Last Updated: 09/26/2026

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Found 35 publications

TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance.

TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance.

Journal: bioRxiv : the preprint server for biology

Published: September 26, 2025

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: September 17, 2024

TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P.

TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: August 16, 2023

TRPM2: bridging calcium and ROS signaling pathways-implications for human diseases.

TRPM2: bridging calcium and ROS signaling pathways-implications for human diseases.

Journal: Frontiers in physiology

Published: May 05, 2023

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Journal: Cell death discovery

Published: April 09, 2021

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.

Journal: Cellular and molecular life sciences : CMLS

Published: March 23, 2021

TRPML1-Emerging Roles in Cancer.

TRPML1-Emerging Roles in Cancer.

Journal: Cells

Published: November 07, 2020

Getting Lost in the Cell-Lysosomal Entrapment of Chemotherapeutics.

Getting Lost in the Cell-Lysosomal Entrapment of Chemotherapeutics.

Journal: Cancers

Published: October 22, 2020

Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance.

Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance.

Journal: Cancers

Published: June 09, 2020

Branched-chain ketoacid overload inhibits insulin action in the muscle.

Branched-chain ketoacid overload inhibits insulin action in the muscle.

Journal: The Journal of biological chemistry

Published: February 21, 2020

Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel.

Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel.

Journal: Cell biochemistry and biophysics

Published: November 22, 2019

The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells.

The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells.

Journal: Advances in experimental medicine and biology

Published: October 25, 2019

Showing 1-12 of 35

Last Updated: 09/26/2026