Yasuhiko Izumi

Kobe, 6588558, Japan

Last Updated: 09/26/2026

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Found 51 publications

In Vivo and in Vitro Characterization of the Anti-inflammatory and Neuroprotective Effects of TPNA10168.

In Vivo and in Vitro Characterization of the Anti-inflammatory and Neuroprotective Effects of TPNA10168.

Journal: Biological & pharmaceutical bulletin

Published: January 28, 2026

Endothelin-1 induces Zfp36 family RNA-binding proteins and restrains cytokine and chemokine production in reactive astrocytes.

Endothelin-1 induces Zfp36 family RNA-binding proteins and restrains cytokine and chemokine production in reactive astrocytes.

Journal: The Journal of biological chemistry

Published: October 31, 2025

PNU-120596, an α7 nicotinic acetylcholine receptor positive allosteric modulator, attenuates microglial activation and protects dopaminergic neurons from inflammatory injury independently of canonical α7 nicotinic acetylcholine receptor signaling.

PNU-120596, an α7 nicotinic acetylcholine receptor positive allosteric modulator, attenuates microglial activation and protects dopaminergic neurons from inflammatory injury independently of canonical α7 nicotinic acetylcholine receptor signaling.

Journal: European journal of pharmacology

Published: July 28, 2025

Perilla-derived chalcone inhibits α-synuclein fibrillization and prevents aggregate-induced disruption of intracellular α-synuclein conformation in neuronal cells.

Perilla-derived chalcone inhibits α-synuclein fibrillization and prevents aggregate-induced disruption of intracellular α-synuclein conformation in neuronal cells.

Journal: Biochemical and biophysical research communications

Published: July 21, 2025

Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures.

Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures.

Journal: Bioorganic & medicinal chemistry

Published: July 15, 2025

Evaluation of the deep learning-based detection of dopaminergic neurons in primary culture: A practical alternative to manual counting.

Evaluation of the deep learning-based detection of dopaminergic neurons in primary culture: A practical alternative to manual counting.

Journal: Journal of neuroscience methods

Published: June 10, 2025

TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathways.

TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathways.

Journal: Journal of pharmacological sciences

Published: June 07, 2025

Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases.

Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases.

Journal: Antioxidants (Basel, Switzerland)

Published: November 01, 2024

Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation.

Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation.

Journal: Glia

Published: March 06, 2024

Isolation and Purification of Harpagogenin as an Nrf2-ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii).

Isolation and Purification of Harpagogenin as an Nrf2-ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii).

Journal: Biological & pharmaceutical bulletin

Published: November 01, 2023

TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway.

TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway.

Journal: Journal of pharmacological sciences

Published: December 27, 2021

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis.

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration

Published: December 13, 2021

Showing 1-12 of 51

Last Updated: 09/26/2026