Yasuhiro Uno
Kagoshima, Japan
Last Updated: 09/26/2026
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Found 243 publications
Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species.
Journal: Biochemical pharmacology
Published: June 15, 2026
Different Roles of Canine Cytochrome P450 2C and 3A Enzymes Involved in the Oxidative Metabolism of Phenobarbital, a Key Anticonvulsant for Dogs: Comparison With Human P450 Enzymes.
Journal: Journal of veterinary pharmacology and therapeutics
Published: April 14, 2026
Biphasic dextromethorphan O-demethylation in tree shrews mediated by liver microsomal cytochromes P450 with high and low affinities.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 18, 2026
Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation.
Journal: Xenobiotica; the fate of foreign compounds in biological systems
Published: January 03, 2026
Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide.
Journal: Biochemical pharmacology
Published: November 22, 2025
Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: July 29, 2025
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.
Journal: Biochemical pharmacology
Published: June 27, 2025
Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 02, 2025
Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations.
Journal: Biochemical pharmacology
Published: May 15, 2025
Efficacy of Sequential Hepatic Vein Embolization Following Portal Vein Embolization in Promoting Regeneration of Liver Volume and Function Before Right-Sided Major Hepatectomy.
Journal: Annals of gastroenterological surgery
Published: January 27, 2025
Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol.
Journal: Biochemical pharmacology
Published: January 19, 2025
Prognostic value of whole-body diffusion-weighted imaging with background body signal suppression in CRPC patients undergoing Ra-223 therapy: an exploratory analysis.
Journal: Japanese journal of radiology
Published: January 17, 2025
Last Updated: 09/26/2026