Yasushi Fujioka

Fujisawa, Japan

Last Updated: 09/26/2026

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Found 13 publications

Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor.

Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 30, 2025

Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.

Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.

Journal: Pharmaceutical research

Published: November 15, 2018

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Journal: Bioorganic & medicinal chemistry

Published: April 01, 2017

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.

Journal: Bioorganic & medicinal chemistry

Published: March 18, 2017

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Journal: Bioorganic & medicinal chemistry

Published: March 11, 2017

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.

Journal: Bioorganic & medicinal chemistry

Published: April 26, 2016

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors-Part 2.

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors-Part 2.

Journal: Bioorganic & medicinal chemistry

Published: April 22, 2016

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.

Journal: Bioorganic & medicinal chemistry

Published: February 23, 2016

Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion.

Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion.

Journal: Journal of pharmaceutical sciences

Published: November 03, 2014

Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information.

Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: June 18, 2014

Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: October 01, 2013

Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.

Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.

Journal: Journal of pharmacological sciences

Published: March 27, 2012

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Last Updated: 09/26/2026