Yasuyuki Higashi

Tsukuba, 3058585, Japan

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 21 publications

Impacts of dosing and drug withdrawal period on tacrolimus-based triple therapy in a non-human primate renal transplantation model.

Impacts of dosing and drug withdrawal period on tacrolimus-based triple therapy in a non-human primate renal transplantation model.

Journal: Transplant immunology

Published: April 26, 2022

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.

Journal: European journal of pharmacology

Published: June 21, 2019

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: July 20, 2018

Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model.

Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model.

Journal: European journal of pharmacology

Published: June 22, 2018

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: July 07, 2017

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Journal: Bioorganic & medicinal chemistry

Published: April 04, 2017

The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates.

The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates.

Journal: Transplantation

Published: November 19, 2016

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Journal: Bioorganic & medicinal chemistry

Published: August 22, 2016

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model.

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model.

Journal: Journal of pharmacological sciences

Published: July 19, 2016

Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys.

Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys.

Journal: International immunopharmacology

Published: June 18, 2016

A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

Journal: Transplant immunology

Published: May 20, 2016

Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor.

Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor.

Journal: European journal of pharmacology

Published: January 07, 2016

Showing 1-12 of 21

Last Updated: 09/26/2026