Yih-chih S. Chan

305 Grattan Street
Melbourne, VIC 3000, Australia

Last Updated: 09/26/2026

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Found 23 publications

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia.

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia.

Journal: bioRxiv : the preprint server for biology

Published: December 23, 2024

Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia.

Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia.

Journal: Cancer discovery

Published: October 22, 2024

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription.

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription.

Journal: EMBO reports

Published: June 27, 2024

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry.

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry.

Journal: Nature genetics

Published: September 22, 2023

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Journal: Molecular cell

Published: June 06, 2023

SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway.

SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway.

Journal: Developmental cell

Published: April 28, 2023

Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.

Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.

Journal: Cancer discovery

Published: January 03, 2023

CRISPR-ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia.

CRISPR-ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia.

Journal: Nature structural & molecular biology

Published: January 03, 2023

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses.

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses.

Journal: Cancer cell

Published: December 13, 2021

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

Journal: Nature cell biology

Published: September 30, 2021

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death.

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death.

Journal: Cancer discovery

Published: April 24, 2021

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy.

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy.

Journal: Communications biology

Published: December 14, 2020

Showing 1-12 of 23

Last Updated: 09/26/2026