Yixiang Sun

Key Laboratory Of Structure Based Drug Design And Discovery, Shenyang Pharmaceutical University 103 Wenhua Road, Shenhe District Shenyang 110016 PR China
Puerto Rico

Last Updated: 09/26/2026

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Found 38 publications

Rational Design and Discovery of CZx-243: A Highly Stable and Orally Bioavailable Triazole CYP51 Inhibitor for the Treatment of Invasive Fungal Infections.

Rational Design and Discovery of CZx-243: A Highly Stable and Orally Bioavailable Triazole CYP51 Inhibitor for the Treatment of Invasive Fungal Infections.

Journal: Journal of medicinal chemistry

Published: July 14, 2026

Design, synthesis, and biological evaluation of indazole-based PLK4 inhibitors.

Design, synthesis, and biological evaluation of indazole-based PLK4 inhibitors.

Journal: RSC medicinal chemistry

Published: July 24, 2025

Design, Synthesis, and Computational Insights into PKMYT1 Inhibitors for the Treatment of Breast Cancer.

Design, Synthesis, and Computational Insights into PKMYT1 Inhibitors for the Treatment of Breast Cancer.

Journal: Biomedicines

Published: July 20, 2025

Discovery of potent and selective PKMYT1 inhibitors for the treatment of CCNE1-amplified cancer.

Discovery of potent and selective PKMYT1 inhibitors for the treatment of CCNE1-amplified cancer.

Journal: European journal of medicinal chemistry

Published: June 18, 2025

Design, synthesis, and biological evaluation of 2-phenylthiazole CYP51 inhibitors.

Design, synthesis, and biological evaluation of 2-phenylthiazole CYP51 inhibitors.

Journal: RSC medicinal chemistry

Published: June 16, 2025

Design, Synthesis, and Biological Activity Evaluation of Deuterated Diphenyl Azole Alcohol-Based CYP51 Inhibitors.

Design, Synthesis, and Biological Activity Evaluation of Deuterated Diphenyl Azole Alcohol-Based CYP51 Inhibitors.

Journal: Journal of medicinal chemistry

Published: June 03, 2025

Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors.

Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors.

Journal: RSC medicinal chemistry

Published: May 15, 2025

Design, synthesis, and activity evaluation of novel tetrazole-based CYP51 inhibitors.

Design, synthesis, and activity evaluation of novel tetrazole-based CYP51 inhibitors.

Journal: Bioorganic chemistry

Published: May 09, 2025

Rational design of CZL-S092: A novel indazole-based PLK4 inhibitor targeting neuroblastoma through virtual screening and fragment-based drug design strategies.

Rational design of CZL-S092: A novel indazole-based PLK4 inhibitor targeting neuroblastoma through virtual screening and fragment-based drug design strategies.

Journal: European journal of medicinal chemistry

Published: April 27, 2025

Discovery of a potent, broad-spectrum and in vivo effective deuterated tetrazole CYP51 inhibitor.

Discovery of a potent, broad-spectrum and in vivo effective deuterated tetrazole CYP51 inhibitor.

Journal: European journal of medicinal chemistry

Published: April 24, 2025

Design, synthesis, and biological evaluation of novel N-(1H-indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors.

Design, synthesis, and biological evaluation of novel N-(1H-indazol-6-yl)benzenesulfonamide derivatives as potent PLK4 inhibitors.

Journal: RSC medicinal chemistry

Published: March 21, 2025

Discovery of highly potent triazole derivatives with broad-spectrum antifungal activity based on Iodiconazole.

Discovery of highly potent triazole derivatives with broad-spectrum antifungal activity based on Iodiconazole.

Journal: European journal of medicinal chemistry

Published: July 24, 2024

Showing 1-12 of 38

Last Updated: 09/26/2026