Yong-yuan B. Guan

74 Zhongshan 2 Rd
Guangzhou, 510080, China

Last Updated: 09/26/2026

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Found 49 publications

ClC-5 knockout mitigates angiotensin II-induced hypertension and endothelial dysfunction.

ClC-5 knockout mitigates angiotensin II-induced hypertension and endothelial dysfunction.

Journal: Life sciences

Published: September 08, 2024

Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway.

Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway.

Journal: Acta pharmacologica Sinica

Published: November 28, 2023

Low Chloride-Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling.

Low Chloride-Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling.

Journal: Hypertension (Dallas, Tex. : 1979)

Published: February 11, 2022

Increased intracellular Cl- concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases.

Increased intracellular Cl- concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases.

Journal: Acta pharmacologica Sinica

Published: October 19, 2021

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl- concentration and activation of SGK1 signaling pathway.

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl- concentration and activation of SGK1 signaling pathway.

Journal: Acta pharmacologica Sinica

Published: October 17, 2021

CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells.

CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells.

Journal: Journal of cardiovascular pharmacology

Published: September 01, 2021

LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension.

LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension.

Journal: Cell proliferation

Published: July 20, 2021

Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl- concentration.

Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl- concentration.

Journal: British journal of pharmacology

Published: November 23, 2020

SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway.

SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway.

Journal: European journal of pharmacology

Published: September 30, 2020

TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation.

TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation.

Journal: Theranostics

Published: October 09, 2019

SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway.

SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway.

Journal: Acta pharmacologica Sinica

Published: September 03, 2019

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation.

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation.

Journal: Acta pharmacologica Sinica

Published: April 21, 2019

Showing 1-12 of 49

Last Updated: 09/26/2026