Yonglei Zhang

Basic Medical Research Innovation Center For Anti Cancer Drugs Of MOE And Jiangsu Key Laboratory Of Bioactive Natural Product Research
Nanjing, 210009, China

Last Updated: 09/26/2026

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Found 16 publications

Development of Dihydroquinoxalinone-Based Dual CDK6/BET Inhibitors for Triple-Negative Breast Cancer Therapy.

Development of Dihydroquinoxalinone-Based Dual CDK6/BET Inhibitors for Triple-Negative Breast Cancer Therapy.

Journal: Journal of medicinal chemistry

Published: March 05, 2026

Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC.

Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC.

Journal: Journal of medicinal chemistry

Published: June 10, 2025

Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity.

Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity.

Journal: European journal of medicinal chemistry

Published: January 15, 2025

Cascade synthesis of miltirone derivatives via arylation, decarboxylation, and aromatization for their potential as antitumor agents.

Cascade synthesis of miltirone derivatives via arylation, decarboxylation, and aromatization for their potential as antitumor agents.

Journal: Bioorganic chemistry

Published: January 10, 2025

Discovery of Dual CDK6/BRD4 Inhibitor Inducing Apoptosis and Increasing the Sensitivity of Ferroptosis in Triple-Negative Breast Cancer.

Discovery of Dual CDK6/BRD4 Inhibitor Inducing Apoptosis and Increasing the Sensitivity of Ferroptosis in Triple-Negative Breast Cancer.

Journal: Journal of medicinal chemistry

Published: November 22, 2024

Polypharmacological Drug Design Guided by Integrating Phenotypic and Restricted Fragment Docking Strategies.

Polypharmacological Drug Design Guided by Integrating Phenotypic and Restricted Fragment Docking Strategies.

Journal: Journal of medicinal chemistry

Published: September 19, 2024

Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis.

Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis.

Journal: Journal of medicinal chemistry

Published: August 24, 2024

Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1.

Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1.

Journal: European journal of medicinal chemistry

Published: March 26, 2024

Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups.

Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups.

Journal: Organic letters

Published: February 13, 2024

Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy.

Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy.

Journal: European journal of medicinal chemistry

Published: October 05, 2023

Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.

Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.

Journal: European journal of medicinal chemistry

Published: July 13, 2023

Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease.

Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: February 24, 2023

Showing 1-12 of 16

Last Updated: 09/26/2026