Yongzhou P. Hu

Hangzhou, 310058, China

Last Updated: 09/26/2026

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Found 68 publications

Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study.

Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study.

Journal: ACS applied bio materials

Published: January 11, 2022

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

Journal: European journal of medicinal chemistry

Published: August 30, 2021

Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.

Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.

Journal: Journal of medicinal chemistry

Published: August 10, 2021

Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis.

Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis.

Journal: Journal of medicinal chemistry

Published: June 01, 2021

Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2.

Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2.

Journal: ACS medicinal chemistry letters

Published: February 23, 2021

Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease.

Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: August 27, 2020

An inherently kidney-targeting near-infrared fluorophore based probe for early detection of acute kidney injury.

An inherently kidney-targeting near-infrared fluorophore based probe for early detection of acute kidney injury.

Journal: Biosensors & bioelectronics

Published: August 12, 2020

Recent advances in FLT3 inhibitors for acute myeloid leukemia.

Recent advances in FLT3 inhibitors for acute myeloid leukemia.

Journal: Future medicinal chemistry

Published: April 22, 2020

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.

Journal: European journal of medicinal chemistry

Published: February 10, 2020

A fluorogenic probe for tracking GSH flux in developing neurons.

A fluorogenic probe for tracking GSH flux in developing neurons.

Journal: Chemical communications (Cambridge, England)

Published: December 12, 2019

Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation.

Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation.

Journal: European journal of medicinal chemistry

Published: December 02, 2019

Physicochemical-property guided design of a highly sensitive probe to image nitrosative stress in the pathology of stroke.

Physicochemical-property guided design of a highly sensitive probe to image nitrosative stress in the pathology of stroke.

Journal: Chemical science

Published: November 11, 2019

Showing 1-12 of 68

Last Updated: 09/26/2026