Yu-tao Hu

Guangdong Provincial Key Laboratory Of New Drug Design And Evaluation
Guangzhou, China

Last Updated: 09/26/2026

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Found 19 publications

G4-Ligand-Directed PROTACs Unveil DR1 as a Novel Ligand-Co-Binding G4-Protein and Reshape G4-Dependent Transcription.

G4-Ligand-Directed PROTACs Unveil DR1 as a Novel Ligand-Co-Binding G4-Protein and Reshape G4-Dependent Transcription.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: November 22, 2025

A novel NAMPT activator ameliorates obesity by repressing ACSL1-dependent lipid synthesis.

A novel NAMPT activator ameliorates obesity by repressing ACSL1-dependent lipid synthesis.

Journal: Acta pharmaceutica Sinica. B

Published: September 03, 2025

Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity.

Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity.

Journal: Journal of medicinal chemistry

Published: August 15, 2025

Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy.

Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: August 02, 2024

Disrupting the protein-protein interaction network of Hsp72 inhibits adipogenic differentiation and lipid synthesis in adipocytes.

Disrupting the protein-protein interaction network of Hsp72 inhibits adipogenic differentiation and lipid synthesis in adipocytes.

Journal: Cellular signalling

Published: July 29, 2024

L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditure.

L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditure.

Journal: Diabetes, obesity & metabolism

Published: July 25, 2024

sgRNA structure optimization and PTG/Cas9 system synergistically boost gene knockout efficiency in an insect.

sgRNA structure optimization and PTG/Cas9 system synergistically boost gene knockout efficiency in an insect.

Journal: International journal of biological macromolecules

Published: July 14, 2024

Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.

Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.

Journal: Journal of medicinal chemistry

Published: July 12, 2024

Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents.

Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents.

Journal: European journal of medicinal chemistry

Published: July 02, 2024

Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism.

Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism.

Journal: European journal of medicinal chemistry

Published: July 12, 2023

Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer.

Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer.

Journal: Journal of medicinal chemistry

Published: May 30, 2023

Palladium oxidative addition complex-enabled synthesis of amino-substituted indolyl-4(3H)-quinazolinones and their antitumor activity evaluation.

Palladium oxidative addition complex-enabled synthesis of amino-substituted indolyl-4(3H)-quinazolinones and their antitumor activity evaluation.

Journal: Organic & biomolecular chemistry

Published: December 21, 2021

Showing 1-12 of 19

Last Updated: 09/26/2026