Yuan Y. Sin

Glasgow, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 23 publications

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells.

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells.

Journal: British journal of pharmacology

Published: November 09, 2025

KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential.

KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential.

Journal: Cell communication and signaling : CCS

Published: October 26, 2025

Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders.

Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders.

Journal: Journal of translational autoimmunity

Published: June 10, 2025

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells.

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells.

Journal: Molecular therapy. Oncology

Published: February 27, 2025

Ang-(1-7) and ET-1 Interplay Through Mas and ETB Receptor Interaction Defines a Novel Vasoprotective Mechanism.

Ang-(1-7) and ET-1 Interplay Through Mas and ETB Receptor Interaction Defines a Novel Vasoprotective Mechanism.

Journal: Hypertension (Dallas, Tex. : 1979)

Published: December 05, 2024

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

Journal: The FEBS journal

Published: August 13, 2024

SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline.

SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline.

Journal: The international journal of biochemistry & cell biology

Published: May 07, 2024

Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability.

Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability.

Journal: FEBS letters

Published: January 16, 2024

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage.

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage.

Journal: EBioMedicine

Published: January 06, 2024

Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC.

Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC.

Journal: Scientific reports

Published: December 21, 2023

Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts.

Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts.

Journal: Biomaterials

Published: March 16, 2020

Basement membrane collagens and disease mechanisms.

Basement membrane collagens and disease mechanisms.

Journal: Essays in biochemistry

Published: June 16, 2019

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Last Updated: 09/26/2026