Yuanzhen Q. Dong

Shanghai, 201203, China

Last Updated: 09/26/2026

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Found 35 publications

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Journal: Journal of medicinal chemistry

Published: May 06, 2026

Development and Validation of a Mechanism-Based Ba/F3-hGHR Bioassay for the Potency Assessment of Recombinant Human Growth Hormone.

Development and Validation of a Mechanism-Based Ba/F3-hGHR Bioassay for the Potency Assessment of Recombinant Human Growth Hormone.

Journal: Analytical biochemistry

Published: April 26, 2026

An integrated bioprocess for the production of insulin icodec in Pichia pastoris.

An integrated bioprocess for the production of insulin icodec in Pichia pastoris.

Journal: Preparative biochemistry & biotechnology

Published: March 18, 2026

Design, synthesis and evaluation of trofinetide prodrug based on diketopiperazine strategy.

Design, synthesis and evaluation of trofinetide prodrug based on diketopiperazine strategy.

Journal: Bioorganic & medicinal chemistry

Published: November 18, 2025

SAR investigation and synergistic optimization of setmelanotide yields a potent, selective, and soluble MC4R agonist.

SAR investigation and synergistic optimization of setmelanotide yields a potent, selective, and soluble MC4R agonist.

Journal: Bioorganic chemistry

Published: October 10, 2025

Design and synthesis of novel thrombopoietin mimetic peptides via dual-mechanistic modification.

Design and synthesis of novel thrombopoietin mimetic peptides via dual-mechanistic modification.

Journal: Bioorganic & medicinal chemistry

Published: June 28, 2025

Design, synthesis, and structure-activity relationship study of novel GLP-1/GIP/GCG triple receptor agonists.

Design, synthesis, and structure-activity relationship study of novel GLP-1/GIP/GCG triple receptor agonists.

Journal: European journal of medicinal chemistry

Published: June 27, 2025

Design, Synthesis, and Biological Evaluation of a Novel Long-Acting Human Complement C3 Inhibitor Synthesized via the PASylation-Lipidation Modular (PLM) Platform.

Design, Synthesis, and Biological Evaluation of a Novel Long-Acting Human Complement C3 Inhibitor Synthesized via the PASylation-Lipidation Modular (PLM) Platform.

Journal: Bioconjugate chemistry

Published: May 13, 2025

Rational Design of Site-Specific Fatty Acid Derivatives to Extend the Half-Life of Fibroblast Growth Factor 21.

Rational Design of Site-Specific Fatty Acid Derivatives to Extend the Half-Life of Fibroblast Growth Factor 21.

Journal: Bioconjugate chemistry

Published: March 14, 2025

Novel bifunctional antibacterial peptides mediated by a covalent conjugation strategy combat priority multidrug-resistant gram-negative pathogens through dual targets.

Novel bifunctional antibacterial peptides mediated by a covalent conjugation strategy combat priority multidrug-resistant gram-negative pathogens through dual targets.

Journal: The Journal of antibiotics

Published: March 04, 2025

Design, synthesis, and biological evaluation of long-acting glucagon-like peptide-1 (GLP-1) conjugates modified with dual fatty acids and a proline-alanine-serine (PAS) polypeptide.

Design, synthesis, and biological evaluation of long-acting glucagon-like peptide-1 (GLP-1) conjugates modified with dual fatty acids and a proline-alanine-serine (PAS) polypeptide.

Journal: Bioorganic & medicinal chemistry

Published: March 02, 2025

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec.

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec.

Journal: Scientific reports

Published: November 19, 2024

Showing 1-12 of 35

Last Updated: 09/26/2026